Issue 47, 2013

A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

Abstract

A copper-catalysed oxidative amidation of aldehydes via N-hydroxysuccinimide ester formation is reported. The methodology employed to prepare amides directly from aldehydes has a very wide scope, is high yielding, and does not need dry conditions. This cross-coupling reaction appears to be simple and makes use of cheap, abundant and easily available reagents.

Graphical abstract: A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

Supplementary files

Article information

Article type
Paper
Submitted
12 Jul 2013
Accepted
14 Oct 2013
First published
14 Oct 2013

Org. Biomol. Chem., 2013,11, 8241-8246

A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

M. Pilo, A. Porcheddu and L. De Luca, Org. Biomol. Chem., 2013, 11, 8241 DOI: 10.1039/C3OB41440J

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