Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids†
Abstract
This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1 : 2 : 1 (α : β : α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues.