Issue 36, 2013

Rhodium(iii)-catalyzed vinylic sp2 C–H bond functionalization: efficient synthesis of pyrido[1,2-α]benzimidazoles and imidazo[1,2-α]pyridines

Abstract

A simple approach for synthesis of novel aza-fused scaffolds such as pyrido[1,2-α]benzimidazoles and imidazo[1,2-α]pyridines was developed by Rh(III)-catalyzed direct oxidative coupling between alkenes and unactivated alkynes without an extra directing group. The method would allow a broad substrate scope, providing fused heterocycles with potential biological properties.

Graphical abstract: Rhodium(iii)-catalyzed vinylic sp2 C–H bond functionalization: efficient synthesis of pyrido[1,2-α]benzimidazoles and imidazo[1,2-α]pyridines

Supplementary files

Article information

Article type
Paper
Submitted
07 Jun 2013
Accepted
19 Jul 2013
First published
23 Jul 2013

Org. Biomol. Chem., 2013,11, 6142-6149

Rhodium(III)-catalyzed vinylic sp2 C–H bond functionalization: efficient synthesis of pyrido[1,2-α]benzimidazoles and imidazo[1,2-α]pyridines

L. Dong, J. Huang, C. Qu, Q. Zhang, W. Zhang, B. Han and C. Peng, Org. Biomol. Chem., 2013, 11, 6142 DOI: 10.1039/C3OB41177J

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