Issue 12, 2013
From the journal:

Organic & Biomolecular Chemistry

Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media†

Ying Zhang,a   Shun-Yi Wang,*a   Xiao-Ping Xu,a   Ran Jianga  and  Shun-Jun Ji*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
E-mail: shunjun@suda.edu.cn
Fax: (+86)-512-65880307
Tel: (+86)-512-65880307

Abstract

Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.

Graphical abstract: Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media

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Article information

DOI
https://doi.org/10.1039/C3OB00045A
Article type
Communication
Submitted
09 Jan 2013
Accepted
30 Jan 2013
First published
01 Feb 2013

Org. Biomol. Chem., 2013,11, 1933-1937

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Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media

Y. Zhang, S. Wang, X. Xu, R. Jiang and S. Ji, Org. Biomol. Chem., 2013, 11, 1933 DOI: 10.1039/C3OB00045A

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