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Issue 6, 2013
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RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines

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Abstract

We synthesized seven new analogues of KRN7000: RCAI-133 and 154–159. RCAI-154, 156 and 158 are secondary-amide analogues having a hydroxy, a methyl or two methyl groups at the α-position of a linear C18-acyl chain, respectively. RCAI-155, 157 and 159 are corresponding N-methylated tertiary amide analogues, and RCAI-133 is the N-methylated KRN7000. Among them, a PBS solution of RCAI-133 induced mouse lymphocytes to produce Th2-biasing cytokines in vivo, while RCAI-154–159 showed only weak or almost no immunostimulatory activity. Therefore, N-methylation led the glycolipid to produce predominantly Th2-type cytokines, while acyl α-substitution was detrimental to activity.

Graphical abstract: RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines

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Publication details

The article was received on 05 Mar 2013, accepted on 10 Apr 2013 and first published on 10 Apr 2013


Article type: Concise Article
DOI: 10.1039/C3MD00073G
Citation: Med. Chem. Commun., 2013,4, 949-955

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    RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines

    T. Tashiro, T. Shigeura, M. Shiozaki, H. Watarai, M. Taniguchi and K. Mori, Med. Chem. Commun., 2013, 4, 949
    DOI: 10.1039/C3MD00073G

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