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Issue 6, 2013
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Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

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Abstract

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.

Graphical abstract: Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

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Publication details

The article was received on 06 Mar 2013, accepted on 23 Apr 2013 and first published on 24 Apr 2013


Article type: Concise Article
DOI: 10.1039/C3MD00077J
Citation: Med. Chem. Commun., 2013,4, 956-961
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    Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

    A. Ciupa, P. A. De Bank, M. F. Mahon, P. J. Wood and L. Caggiano, Med. Chem. Commun., 2013, 4, 956
    DOI: 10.1039/C3MD00077J

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