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Issue 11, 2013
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Design, synthesis and antiproliferative activity of indole analogues of indanocine

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Abstract

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

Graphical abstract: Design, synthesis and antiproliferative activity of indole analogues of indanocine

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Publication details

The article was received on 16 Jul 2013, accepted on 16 Sep 2013 and first published on 17 Sep 2013


Article type: Concise Article
DOI: 10.1039/C3MD00200D
Med. Chem. Commun., 2013,4, 1452-1456
  • Open access: Creative Commons BY license
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    Design, synthesis and antiproliferative activity of indole analogues of indanocine

    G. A. Tunbridge, J. Oram and L. Caggiano, Med. Chem. Commun., 2013, 4, 1452
    DOI: 10.1039/C3MD00200D

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