Issue 70, 2013
From the journal:

Chemical Communications

Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis†

Gabriel T. M. Mashabelaab  and  Florian P. Seebeck*a  

* Corresponding authors

a Department for Chemistry, University of Basel, St. Johanns-Ring 19, Basel, Switzerland
E-mail: florian.seebeck@unibas.ch

b Department of Chemistry, University of Cape Town, Rondebosch, South Africa

Abstract

OvoA is an iron(II) dependent sulfoxide synthase which catalyzes the first step in ovothiol A biosynthesis. This enzyme sulphurizes the C5 position of the imidazole side chain of L-histidine. We report the substrate specificity profile of this catalyst and present data which indicate that OvoA catalysis follows an thiol-ene type mechanism.

Graphical abstract: Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis

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Article information

DOI
https://doi.org/10.1039/C3CC42594K
Article type
Communication
Submitted
09 Apr 2013
Accepted
03 Jul 2013
First published
04 Jul 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 7714-7716

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Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis

G. T. M. Mashabela and F. P. Seebeck, Chem. Commun., 2013, 49, 7714 DOI: 10.1039/C3CC42594K

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