Issue 81, 2013
From the journal:

Chemical Communications

One-pot total chemical synthesis of human α-synuclein†

Bruno Fauvet,‡a   Sara M. Butterfield,‡a   Jonas Fuks,a   Ashraf Brikb  and  Hilal A. Lashuel*a  

* Corresponding authors

a École Polytechnique Fédérale de Lausanne (EPFL), Station 19, CH-1015 Lausanne, Switzerland
E-mail: hilal.lashuel@epfl.ch

b Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Graphical abstract: One-pot total chemical synthesis of human α-synuclein

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Article information

DOI
https://doi.org/10.1039/C3CC45353G
Article type
Communication
Submitted
15 Jul 2013
Accepted
02 Aug 2013
First published
02 Aug 2013

Chem. Commun., 2013,49, 9254-9256

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One-pot total chemical synthesis of human α-synuclein

B. Fauvet, S. M. Butterfield, J. Fuks, A. Brik and H. A. Lashuel, Chem. Commun., 2013, 49, 9254 DOI: 10.1039/C3CC45353G

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