Issue 71, 2013
From the journal:

Chemical Communications

Phenylalanine-containing cyclic dipeptides – the lowest molecular weight hydrogelators based on unmodified proteinogenic amino acids†

Alexander J. Kleinsmanna  and  Boris J. Nachtsheim*a  

* Corresponding authors

a University of Tuebingen, Institute of Organic Chemistry, Auf der Morgenstelle 18, D-72076 Tuebingen, Germany
E-mail: boris.nachtsheim@uni-tuebingen.de
Fax: +49 7071 295897
Tel: +49 7071 29 72035

Abstract

Cyclic dipeptides (diketopiperazines – DKPs) that are based on the proteinogenic amino acid phenylalanine in combination with serine, cysteine, glutamate, histidine and lysine are described as simple and remarkable low molecular weight hydrogelators. Blends of selected DKPs show remarkable pH-dependent properties and can be applied as easy to tune materials in drug delivery.

Graphical abstract: Phenylalanine-containing cyclic dipeptides – the lowest molecular weight hydrogelators based on unmodified proteinogenic amino acids

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Article information

DOI
https://doi.org/10.1039/C3CC44110E
Article type
Communication
Submitted
31 May 2013
Accepted
03 Jul 2013
First published
03 Jul 2013

Chem. Commun., 2013,49, 7818-7820

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Phenylalanine-containing cyclic dipeptides – the lowest molecular weight hydrogelators based on unmodified proteinogenic amino acids

A. J. Kleinsmann and B. J. Nachtsheim, Chem. Commun., 2013, 49, 7818 DOI: 10.1039/C3CC44110E

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