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Issue 71, 2013
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One-pot squaric acid diester mediated aqueous protein conjugation

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Abstract

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.

Graphical abstract: One-pot squaric acid diester mediated aqueous protein conjugation

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Article information


Submitted
29 May 2013
Accepted
05 Jul 2013
First published
08 Jul 2013

Chem. Commun., 2013,49, 7815-7817
Article type
Communication

One-pot squaric acid diester mediated aqueous protein conjugation

F. Wurm, T. Steinbach and H. Klok, Chem. Commun., 2013, 49, 7815
DOI: 10.1039/C3CC44039G

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