Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.
Y. Zhang, C. Wang, C. Xu, C. Yang, Z. Zhang, H. Yan and K. Liu, Chem. Commun., 2013, 49, 7286 DOI: 10.1039/C3CC43334J
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