Issue 41, 2013

Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones

Abstract

A catalytic highly enantioselective silver–DTBM-segphos catalyzed cycloaddition of α-iminoesters with alkylidene azlactones is reported. This procedure provides an effective access to 4-aminopyrrolidine-2,4-dicarboxylate derivatives with high diastereo- and enantioselectivity.

Graphical abstract: Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2013
Accepted
26 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4649-4651

Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones

M. González-Esguevillas, J. Adrio and J. C. Carretero, Chem. Commun., 2013, 49, 4649 DOI: 10.1039/C3CC41663A

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