Issue 13, 2012

Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

Abstract

Calcein was delivered from a functional coating into viable cells on top of it, upon the application of an electrochemical stimulus. The dye was loaded in liposomes stably embedded in a sandwich of polyelectrolyte multilayers. The covering multilayer was optimized with respect to its chemical composition to be resistant to galvanostatic conditions and to allow for cell growth. Additionally, spatial control over the release was achieved by two different patterning methods: (1) coating the indium tin oxide electrode by a micro-patterned insulator and (2) directly patterning the electrode. The release kinetics could be tuned by regulating the current density.

Graphical abstract: Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

Supplementary files

Article information

Article type
Paper
Submitted
30 Nov 2011
Accepted
17 Jan 2012
First published
20 Feb 2012

Soft Matter, 2012,8, 3641-3648

Electrochemically driven delivery to cells from vesicles embedded in polyelectrolyte multilayers

N. Graf, A. Tanno, A. Dochter, N. Rothfuchs, J. Vörös and T. Zambelli, Soft Matter, 2012, 8, 3641 DOI: 10.1039/C2SM07272F

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