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Issue 3, 2012
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A surface-immobilized cytochrome c variant provides a pH-controlled molecular switch

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Abstract

The K72A/K73H/K79A mutant of yeast iso-1-cytochrome c immobilized on a conductive substrate reversibly interconverts between the native-like, His-Met heme-ligated form and a His-His-ligated conformer with remarkably different redox and enzymatic properties. This transition is activated by changing the pH in a narrow range around neutrality.

Graphical abstract: A surface-immobilized cytochrome c variant provides a pH-controlled molecular switch

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Publication details

The article was received on 18 Oct 2011, accepted on 17 Nov 2011 and first published on 21 Nov 2011


Article type: Edge Article
DOI: 10.1039/C1SC00821H
Chem. Sci., 2012,3, 807-810

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    A surface-immobilized cytochrome c variant provides a pH-controlled molecular switch

    C. A. Bortolotti, L. Paltrinieri, S. Monari, A. Ranieri, M. Borsari, G. Battistuzzi and M. Sola, Chem. Sci., 2012, 3, 807
    DOI: 10.1039/C1SC00821H

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