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Issue 35, 2012
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Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water

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Abstract

Asymmetric Michael reactions and enantioselective protonations between enones and thiols were catalyzed by a Sc(OTf)3–chiral 2,2′-bipyridine complex in water. The remarkable governing of the enantioselectivity for simple introduction of protons despite their abnormally high mobility in water may provide us with new synthetic opportunities as well as significant chemical advances.

Graphical abstract: Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water

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Publication details

The article was received on 11 Jun 2012, accepted on 06 Jul 2012 and first published on 06 Jul 2012


Article type: Paper
DOI: 10.1039/C2OB26264A
Org. Biomol. Chem., 2012,10, 7134-7147

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    Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water

    T. Kitanosono, M. Sakai, M. Ueno and S. Kobayashi, Org. Biomol. Chem., 2012, 10, 7134
    DOI: 10.1039/C2OB26264A

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