Issue 35, 2012
From the journal:

Organic & Biomolecular Chemistry

Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions†

Chuan Liu,a   Wei Zhang,a   Li-Xin Daia  and  Shu-Li You*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P.R. China
E-mail: slyou@sioc.ac.cn
Fax: (+86) 21-54925087

Abstract

Lewis acid-catalyzed cascade dearomatization of N-substituted tryptophols via Michael addition reaction was developed. The generality of the method has been demonstrated by the synthesis of versatile furoindoline derivatives with a quaternary carbon center in good yields.

Graphical abstract: Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions

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Article information

DOI
https://doi.org/10.1039/C2OB26139A
Article type
Paper
Submitted
14 Jun 2012
Accepted
05 Jul 2012
First published
05 Jul 2012

Org. Biomol. Chem., 2012,10, 7177-7183

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Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions

C. Liu, W. Zhang, L. Dai and S. You, Org. Biomol. Chem., 2012, 10, 7177 DOI: 10.1039/C2OB26139A

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