Issue 16, 2012
From the journal:

Organic & Biomolecular Chemistry

A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles†

Feng Zhou,a   Miao Dinga  and  Jian Zhou*a  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, P.R. China
E-mail: jzhou@chem.ecnu.edu.cn

Abstract

The first Ritter reaction of 3-substituted 3-hydroxyoxindoles with nitriles, catalyzed by HClO4, is developed, which enables the synthesis of 3-substituted 3-aminooxindoles in good to excellent yield with rich diversity.

Graphical abstract: A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles

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Article information

DOI
https://doi.org/10.1039/C2OB25319D
Article type
Communication
Submitted
13 Feb 2012
Accepted
05 Mar 2012
First published
05 Mar 2012

Org. Biomol. Chem., 2012,10, 3178-3181

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A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles

F. Zhou, M. Ding and J. Zhou, Org. Biomol. Chem., 2012, 10, 3178 DOI: 10.1039/C2OB25319D

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