Issue 16, 2012
From the journal:

Organic & Biomolecular Chemistry

An efficient synthetic method for allyl-epoxides viaallylation of α-haloketones or esters with allylmagnesium bromide†

Liyuan Fan,a   Min Zhanga  and  Songlin Zhang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science of Soochow University, Suzhou 215123, People's Republic of China
E-mail: zhangsl@suda.edu.cn

Abstract

A simple, efficient, and non-metal-catalyzed synthetic method for allyl-epoxides and diallyl-epoxides by allylation of α-haloketones and esters with allylmagnesium bromide in mild conditions is reported in this article. It inherited some advantages of the organomagnesium reagents such as availability, operational simplicity and low toxicity.

Graphical abstract: An efficient synthetic method for allyl-epoxides via allylation of α-haloketones or esters with allylmagnesium bromide

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Article information

DOI
https://doi.org/10.1039/C2OB00051B
Article type
Communication
Submitted
09 Jan 2012
Accepted
15 Feb 2012
First published
17 Feb 2012

Org. Biomol. Chem., 2012,10, 3182-3184

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An efficient synthetic method for allyl-epoxides via allylation of α-haloketones or esters with allylmagnesium bromide

L. Fan, M. Zhang and S. Zhang, Org. Biomol. Chem., 2012, 10, 3182 DOI: 10.1039/C2OB00051B

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