Issue 24, 2012
From the journal:

Organic & Biomolecular Chemistry

Enantioselective Friedel–Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(ii) complex†

Jimil Georgea  and  B. V. Subba Reddy*a  

* Corresponding authors

a Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh, India
E-mail: basireddy@iict.res.in
Fax: +91-040-27160512
Tel: +91-040-27193535

Abstract

The glucosamine derived glucoBOX-Cu(II) complex was found to be a unique catalytic system for enantioselective Friedel–Crafts alkylation of indoles with 2-enoylpyridine-1-oxides. A large number of 3-alkylated indole derivatives were prepared using 5 mol% glucoBOX-Cu(II) complex in excellent yields with high enantioselectivity up to 99% ee.

Graphical abstract: Enantioselective Friedel–Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(ii) complex

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25315A
Article type
Paper
Submitted
13 Feb 2012
Accepted
17 Apr 2012
First published
18 Apr 2012

Org. Biomol. Chem., 2012,10, 4731-4738

Permissions

Request permissions

Enantioselective Friedel–Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex

J. George and B. V. S. Reddy, Org. Biomol. Chem., 2012, 10, 4731 DOI: 10.1039/C2OB25315A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements