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Issue 7, 2012
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A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA

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Abstract

The interactions of four antitumor azolato-bridged dinuclear platinum(II) complexes, [{cis-Pt(NH3)2}2(μ-OH)(μ-azolato)]2+, with calf thymus DNA were monitored dose- and time-dependently, by using circular dichroism. Complexes 1–4 reacted with DNA via a two-step interaction that comprised a prompt diffusion-controlled reaction, which induced a B- to C-form transition, and a relatively slow temperature-dependent reaction.

Graphical abstract: A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(ii) complexes with calf thymus DNA

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Publication details

The article was received on 01 Feb 2012, accepted on 03 Apr 2012 and first published on 26 Apr 2012


Article type: Communication
DOI: 10.1039/C2MT20022H
Citation: Metallomics, 2012,4, 641-644

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    A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA

    M. Uemura, Y. Yoshikawa, M. Chikuma and S. Komeda, Metallomics, 2012, 4, 641
    DOI: 10.1039/C2MT20022H

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