Issue 8, 2012

The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

Abstract

Four analogues of lactocin S, an antimicrobial lantibiotic peptide produced by Lactobacillus sakei L45, have been generated using solid-phase peptide chemistry. These analogues serve a dual purpose in enhancing the oxidative stability to atmospheric oxygen by removing susceptible sulfur atoms, while examining the structure–activity relationship of this biologically significant peptide.

Graphical abstract: The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

Supplementary files

Article information

Article type
Concise Article
Submitted
22 Jan 2012
Accepted
20 Feb 2012
First published
16 Mar 2012

Med. Chem. Commun., 2012,3, 971-975

The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

S. M. K. McKinnie, A. C. Ross, M. J. Little and J. C. Vederas, Med. Chem. Commun., 2012, 3, 971 DOI: 10.1039/C2MD20014G

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