Issue 78, 2012
From the journal:

Chemical Communications

Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging†

Katsuhiko Suzuki,ab   Atsuko Ohtake,ab   Yukishige Ito*ab  and  Osamu Kanie*abc  

* Corresponding authors

a RIKEN Advanced Science Institute (ASI), Wako, Saitama, Japan

b Japan Science and Technology Agency (JST), ERATO, Wako, Saitama, Japan

c Tokai University, Institute of Glycoscience, Hiratsuka, Kanagawa, Japan
E-mail: kanie@tokai-u.jp
Fax: +81 463-50-2432
Tel: +81 463-1211 ext 4656

Abstract

A cytidine 5′-monophosphate (CMP)-sialic acid analogue carrying a fluorescent reporter group, an inhibitor of sialyltransferase, was synthesised in order to investigate glycan synthesis events in cells. The compound was found to be a substrate of a CMP-sialic acid transporter, and specific Golgi vesicles were visualised in the cells.

Graphical abstract: Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

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Article information

DOI
https://doi.org/10.1039/C2CC34605B
Article type
Communication
Submitted
27 Jun 2012
Accepted
13 Aug 2012
First published
14 Aug 2012

Chem. Commun., 2012,48, 9744-9746

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Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

K. Suzuki, A. Ohtake, Y. Ito and O. Kanie, Chem. Commun., 2012, 48, 9744 DOI: 10.1039/C2CC34605B

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