Issue 62, 2012
From the journal:

Chemical Communications

The asymmetric synthesis of CF3- or –CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst†

Jin-Hong Lin,a   Guoqiang Zong,a   Ruo-Bing Du,a   Ji-Chang Xiao*a  and  Shubin Liu*b  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China
E-mail: jchxiao@sioc.ac.cn

b Research Computing Center, University of North Carolina, Chapel Hill, USA
E-mail: shubin_liu@unc.edu

Abstract

CF3- or –CF2-containing tetrahydroquinolines have been asymmetrically synthesized from the reaction of fluorinated N-arylimines with benzyl N-vinylcarbamate in the presence of a chiral phosphoric acid.

Graphical abstract: The asymmetric synthesis of CF3- or –CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst

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Article information

DOI
https://doi.org/10.1039/C2CC18064B
Article type
Communication
Submitted
24 Dec 2011
Accepted
11 Jun 2012
First published
13 Jun 2012

Chem. Commun., 2012,48, 7738-7740

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The asymmetric synthesis of CF3- or –CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst

J. Lin, G. Zong, R. Du, J. Xiao and S. Liu, Chem. Commun., 2012, 48, 7738 DOI: 10.1039/C2CC18064B

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