Issue 14, 2012
From the journal:

Analyst

Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)†

Sarah J. R. Staton,‡a   Paul V. Jones,a   Ginger Ku,b   S. Douglass Gilman,c   Indu Kheterpalb  and  Mark A. Hayes*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, USA
E-mail: mhayes@asu.edu
Fax: +1 480-965-2747
Tel: +1 480-965-2566

b Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA

c Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA

Abstract

Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.

Graphical abstract: Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)

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Article information

DOI
https://doi.org/10.1039/C2AN35138B
Article type
Communication
Submitted
31 Jan 2012
Accepted
18 Apr 2012
First published
11 May 2012

Analyst, 2012,137, 3227-3229

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Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)

S. J. R. Staton, P. V. Jones, G. Ku, S. D. Gilman, I. Kheterpal and M. A. Hayes, Analyst, 2012, 137, 3227 DOI: 10.1039/C2AN35138B

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