Zinc-chelated imidazole groups for DNA polyion complex formation

Shoichiro Asayama; Satoshi Nishinohara; Hiroyoshi Kawakami

doi:10.1039/C1MT00019E

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Zinc-chelated imidazolegroups for DNA polyion complex formation†‡

Shoichiro Asayama,*^a Satoshi Nishinohara^a and Hiroyoshi Kawakami^a

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Tokyo Metropolitan University, Japan
E-mail: asayama-shoichiro@tmu.ac.jp
Fax: +81-42-677-2821
Tel: +81-42-677-1111, ext. 4976

Abstract

This communication presents the pH-dependent chelation of Zn²⁺ ions with the imidazole groups of poly(1-vinylimidazole) (PVIm) and DNA polyion complex formation with the zinc-chelated PVIm (PVIm-Zn) via chelated Zn²⁺ ions. The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression.