Jump to main content
Jump to site search

Issue 4, 2011
Previous Article Next Article

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Author affiliations

Abstract

A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure–activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF3 group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.

Graphical abstract: Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

Back to tab navigation

Supplementary files

Article information


Submitted
27 Nov 2010
Accepted
27 Jan 2011
First published
28 Feb 2011

Med. Chem. Commun., 2011,2, 315-320
Article type
Concise Article

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

G. Chen, H. Xia, Y. Cai, D. Ma, J. Yuan and C. Yuan, Med. Chem. Commun., 2011, 2, 315
DOI: 10.1039/C0MD00236D

Search articles by author

Spotlight

Advertisements