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Issue 7, 2011
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Separation of parasites from human blood using deterministic lateral displacement

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Abstract

We present the use of a simple microfluidic technique to separate living parasites from human blood. Parasitic trypanosomatids cause a range of human and animal diseases. African trypanosomes, responsible for human African trypanosomiasis (sleeping sickness), live free in the blood and other tissue fluids. Diagnosis relies on detection and due to their often low numbers against an overwhelming background of predominantly red blood cells it is crucial to separate the parasites from the blood. By modifying the method of deterministic lateral displacement, confining parasites and red blood cells in channels of optimized depth which accentuates morphological differences, we were able to achieve separation thus offering a potential route to diagnostics.

Graphical abstract: Separation of parasites from human blood using deterministic lateral displacement

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Publication details

The article was received on 03 Nov 2010, accepted on 20 Jan 2011 and first published on 18 Feb 2011


Article type: Paper
DOI: 10.1039/C0LC00560F
Citation: Lab Chip, 2011,11, 1326-1332

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    Separation of parasites from human blood using deterministic lateral displacement

    S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Lab Chip, 2011, 11, 1326
    DOI: 10.1039/C0LC00560F

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