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Issue 8, 2011
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Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

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Abstract

The incorporation of an artificial 5-methyl-2,2′-bipyridine nucleoside at the 5′ terminus of an otherwise self-complementary oligonucleotide sequence opens up the opportunity of metal-mediated aggregation of DNA double helices triggered by the addition of the respective metal ions. Interestingly, two-dimensional aggregates (DNA monolayers) are formed in the presence of nickel(II), whereas copper(II) leads to the formation of three-dimensional disc-shaped structures. With iron(II), a coexistence of both types of aggregates had been observed previously. Models are proposed in which these observations are explained based on geometrical considerations. The artificial nucleoside itself represents a rare example for a C1-symmetric chiral derivative of 2,2′-bipyridine, enabling the formation of four isomeric octahedral complexes.

Graphical abstract: Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

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Article information


Submitted
11 Nov 2010
Accepted
20 Dec 2010
First published
20 Jan 2011

Dalton Trans., 2011,40, 1802-1807
Article type
Paper

Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

N. Megger, L. Welte, F. Zamora and J. Müller, Dalton Trans., 2011, 40, 1802
DOI: 10.1039/C0DT01569E

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