Issue 18, 2011
From the journal:

Chemical Communications

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA†

David Pearson,a   Antje Hienzsch,a   Mirko Wagner,a   Daniel Globisch,a   Veronika Reiter,a   Dilek Özdena  and  Thomas Carell*a  

* Corresponding authors

a Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, LMU Munich, Butenandtstrasse 5–13, 81377 Munich, Germany
E-mail: thomas.carell@cup.uni-muenchen.de
Fax: +49 892 1807 7756
Tel: +49 892 1807 7750

Abstract

RNA nucleosides are often naturally modified into complex non-canonical structures with key biological functions. Here we report LC-MS quantification of the Ar(p) and Gr(p) 2′-ribosylated nucleosides in tRNA using deuterium labelled standards, and the first detection of Gr(p) in complex fungi.

Graphical abstract: LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

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Article information

DOI
https://doi.org/10.1039/C1CC11011J
Article type
Communication
Submitted
21 Feb 2011
Accepted
13 Mar 2011
First published
29 Mar 2011

Chem. Commun., 2011,47, 5196-5198

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LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

D. Pearson, A. Hienzsch, M. Wagner, D. Globisch, V. Reiter, D. Özden and T. Carell, Chem. Commun., 2011, 47, 5196 DOI: 10.1039/C1CC11011J

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