Issue 32, 2011
From the journal:

Chemical Communications

Effective cell uptake of nanoassemblies of a fluorescent amphiphilic cyclodextrin and an anionic porphyrin†

Antonino Mazzaglia,*a   Antonio Valerio,b   Norberto Micali,c   Valentina Villari,c   Fabiana Quaglia,d   Maria Angela Castriciano,a   Luigi Monsù Scolaro,ae   Maria Giuffrè,f   Gabriel Siracusanof  and  Maria Teresa Sciortino*f  

* Corresponding authors

a CNR-ISMN Istituto per lo Studio dei Materiali Nanostrutturati, V. le F. Stagno d'Alcontres 31, Messina, Italy
E-mail: antonino.mazzaglia@ismn.cnr.it
Fax: +390903974108
Tel: +390903974108

b Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta” Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy

c CNR-IPCF Istituto per i Processi Chimico-Fisici, V. le F. Stagno d'Alcontres 37, Faro Superiore, Messina, Italy

d Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy

e Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica dell'Università di Messina, and C.I.R.C.M.S.B, V. le F. Stagno d'Alcontres 31, Messina, Italy

f Dipartimento di Scienze della Vita, Sezione di Microbiologia, Genetica e Biologia Molecolare, Università di Messina, V. le F. Stagno d'Alcontres 31, Messina, Italy
E-mail: mtsciortino@unime.it

Abstract

An emitting nanoassembly composed of a novel amphiphilic cyclodextrin functionalised with a covalently appended fluorophore and an anionic porphyrin internalizes effectively in tumor cells, allowing simultaneously the detection of carrier and photosensitiser.

Graphical abstract: Effective cell uptake of nanoassemblies of a fluorescent amphiphilic cyclodextrin and an anionic porphyrin

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Article information

DOI
https://doi.org/10.1039/C1CC12821C
Article type
Communication
Submitted
13 May 2011
Accepted
21 Jun 2011
First published
13 Jul 2011

Chem. Commun., 2011,47, 9140-9142

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Effective cell uptake of nanoassemblies of a fluorescent amphiphilic cyclodextrin and an anionic porphyrin

A. Mazzaglia, A. Valerio, N. Micali, V. Villari, F. Quaglia, M. A. Castriciano, L. M. Scolaro, M. Giuffrè, G. Siracusano and M. T. Sciortino, Chem. Commun., 2011, 47, 9140 DOI: 10.1039/C1CC12821C

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