Issue 26, 2011
From the journal:

Chemical Communications

A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging†

Guangming Qiao,a   Linhai Zhuo,a   Yuan Gao,a   Lijuan Yu,a   Na Lia  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn

Abstract

We demonstrate a tumor mRNA-dependent drug carrier for controlled release of doxorubicin (Dox) and intracellular imaging based on gold nanoparticle–molecular beacon. Fluorescent Dox is released effectively and induces apoptosis in breast cancer cells but not in normal cells. Significantly, the release of Dox is correlated positively with the quantities of tumor mRNA, which is according to various stages of tumor progression, and so can decrease effectively side effects of Dox.

Graphical abstract: A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC11490E
Article type
Communication
Submitted
15 Mar 2011
Accepted
26 Apr 2011
First published
17 May 2011

Chem. Commun., 2011,47, 7458-7460

Permissions

Request permissions

A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

G. Qiao, L. Zhuo, Y. Gao, L. Yu, N. Li and B. Tang, Chem. Commun., 2011, 47, 7458 DOI: 10.1039/C1CC11490E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements