Issue 24, 2010

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

Abstract

Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.

Graphical abstract: Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

Supplementary files

Article information

Article type
Paper
Submitted
22 Jun 2010
Accepted
02 Sep 2010
First published
30 Sep 2010

Org. Biomol. Chem., 2010,8, 5583-5590

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

P. Magrone, F. Cavallo, W. Panzeri, D. Passarella and S. Riva, Org. Biomol. Chem., 2010, 8, 5583 DOI: 10.1039/C0OB00304B

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