Issue 9, 2010
From the journal:

Molecular BioSystems

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models†‡

Tom A. Barr,b   Martin Krembuszewski,a   Manish Gupta,a   David Grayb  and  Juan C. Mareque-Rivas*a  

* Corresponding authors

a School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom EH9 3JJ
E-mail: juan.mareque@ed.ac.uk
Fax: +44-131-650-4743
Tel: +44-131-650-4750

b Institute of Immunology & Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, United Kingdom EH9 3JT

Abstract

We attached the pathogen associated molecular pattern Kdo2-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo.

Graphical abstract: Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models

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Article information

DOI
https://doi.org/10.1039/C002066D
Article type
Communication
Submitted
01 Feb 2010
Accepted
30 Mar 2010
First published
20 Apr 2010

Mol. BioSyst., 2010,6, 1572-1575

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Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models

T. A. Barr, M. Krembuszewski, M. Gupta, D. Gray and J. C. Mareque-Rivas, Mol. BioSyst., 2010, 6, 1572 DOI: 10.1039/C002066D

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