Issue 16, 2010
From the journal:

Lab on a Chip

Real-time, step-wise, electrical detection ofprotein molecules using dielectrophoretically aligned SWNT-film FET aptasensors

Taechang An,a   Ki Su Kim,b   Sei Kwang Hahn*b  and  Geunbae Lim*ac  

* Corresponding authors

a Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Korea
E-mail: limmems@postech.ac.kr

b Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Korea
E-mail: skhanb@postech.ac.kr

c Department of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Korea

Abstract

Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target proteins with a large binding surface area. Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds.

Graphical abstract: Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors

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Article information

DOI
https://doi.org/10.1039/C005276K
Article type
Communication
Submitted
30 Apr 2010
Accepted
18 Jun 2010
First published
09 Jul 2010

Lab Chip, 2010,10, 2052-2056

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Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors

T. An, K. S. Kim, S. K. Hahn and G. Lim, Lab Chip, 2010, 10, 2052 DOI: 10.1039/C005276K

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