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Issue 17, 2010
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Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers

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Abstract

This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers (hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.

Graphical abstract: Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers

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Publication details

The article was received on 19 Nov 2009, accepted on 28 Jan 2010 and first published on 24 Feb 2010


Article type: Paper
DOI: 10.1039/B924370D
Citation: Phys. Chem. Chem. Phys., 2010,12, 4418-4422

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    Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers

    Y. Yang, W. Song, A. Wang, P. Zhu, J. Fei and J. Li, Phys. Chem. Chem. Phys., 2010, 12, 4418
    DOI: 10.1039/B924370D

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