Issue 9, 2010
From the journal:

CrystEngComm

High-pressure structural studies of the pharmaceutical, chlorothiazide†

Iain D. H. Oswald,*ab   Alistair R. Lennie,c   Colin R. Pulhamb  and  Kenneth Shanklandd  

* Corresponding authors

a Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, UK
E-mail: iain.oswald@strath.ac.uk
Fax: +44 (0)141 552 2562
Tel: +44 (0)141 548 2157

b School of Chemistry and Centre for Science at Extreme Conditions, University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh, UK

c STFC, Daresbury Laboratory, Warrington, UK

d Reading School of Pharmacy, University of Reading, PO Box 226, Whiteknights, Reading, UK

Abstract

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.

Graphical abstract: High-pressure structural studies of the pharmaceutical, chlorothiazide

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Article information

DOI
https://doi.org/10.1039/C001355B
Article type
Paper
Submitted
21 Jan 2010
Accepted
16 Apr 2010
First published
11 May 2010

CrystEngComm, 2010,12, 2533-2540

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High-pressure structural studies of the pharmaceutical, chlorothiazide

I. D. H. Oswald, A. R. Lennie, C. R. Pulham and K. Shankland, CrystEngComm, 2010, 12, 2533 DOI: 10.1039/C001355B

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