Jump to main content
Jump to site search

Issue 9, 2010
Previous Article Next Article

High-pressure structural studies of the pharmaceutical, chlorothiazide

Author affiliations

Abstract

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.

Graphical abstract: High-pressure structural studies of the pharmaceutical, chlorothiazide

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Jan 2010, accepted on 16 Apr 2010 and first published on 11 May 2010


Article type: Paper
DOI: 10.1039/C001355B
CrystEngComm, 2010,12, 2533-2540

  •   Request permissions

    High-pressure structural studies of the pharmaceutical, chlorothiazide

    I. D. H. Oswald, A. R. Lennie, C. R. Pulham and K. Shankland, CrystEngComm, 2010, 12, 2533
    DOI: 10.1039/C001355B

Search articles by author

Spotlight

Advertisements