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Issue 9, 2010
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High-pressure structural studies of the pharmaceutical, chlorothiazide

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Abstract

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.

Graphical abstract: High-pressure structural studies of the pharmaceutical, chlorothiazide

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Article information


Submitted
21 Jan 2010
Accepted
16 Apr 2010
First published
11 May 2010

CrystEngComm, 2010,12, 2533-2540
Article type
Paper

High-pressure structural studies of the pharmaceutical, chlorothiazide

I. D. H. Oswald, A. R. Lennie, C. R. Pulham and K. Shankland, CrystEngComm, 2010, 12, 2533
DOI: 10.1039/C001355B

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