Issue 9, 2010
From the journal:

CrystEngComm

Pressure-induced structural changes in wet vitamin B12†

Francesca P. A. Fabbiani,*a   Gernot Buth,b   Birger Dittrichc  and  Heidrun Sowaa  

* Corresponding authors

a Georg-August-Universität Göttingen, GZG, Abteilung Kristallographie, Göttingen, Germany
E-mail: ffabbia@gwdg.de
Fax: +49 551 399521
Tel: +49 551 393935

b Karlsruhe Institute of Technology, Institut für Synchrotronstrahlung (ISS), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany

c Georg-August-Universität Göttingen, Institut für Anorganische Chemie, Göttingen, Germany

Abstract

The effects of pressure on the structure of cyanocobalamin (vitamin B12) have been investigated by compressing a single crystal grown from water together with its mother liquor to 1.0 GPa. The structure of a crystal grown from water in situ in a capillary has also been re-determined at room temperature and pressure. A conformational rearrangement of selected amide side chains, reduced displacement parameters and remarkable solvent ordering have been observed at high pressure.

Graphical abstract: Pressure-induced structural changes in wet vitamin B12

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Article information

DOI
https://doi.org/10.1039/C003378B
Article type
Paper
Submitted
18 Feb 2010
Accepted
17 Apr 2010
First published
19 May 2010

CrystEngComm, 2010,12, 2541-2550

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Pressure-induced structural changes in wet vitamin B12

F. P. A. Fabbiani, G. Buth, B. Dittrich and H. Sowa, CrystEngComm, 2010, 12, 2541 DOI: 10.1039/C003378B

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