Issue 31, 2010
From the journal:

Chemical Communications

Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium(salalen) catalyst†

Yoshifumi Sakai,a   Junko Mitote,a   Kazuhiro Matsumotoa  and  Tsutomu Katsuki‡*a  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Graduate School, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
E-mail: katsuscc@chem.kyushu-univ.jp
Fax: +81 92 642 2607

Abstract

Room-temperature synthesis of enantioenriched non-protected cyanohydrins using acetone cyanohydrin as the cyanide source was achieved by V(salalen) catalyst. Aliphatic aldehydes underwent the cyanation with 89–95% ee in the presence of only 0.2–0.4 mol% catalyst. Aromatic cyanohydrins were also obtained in high enantiomeric excesses under modified conditions.

Graphical abstract: Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium(salalen) catalyst

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Article information

DOI
https://doi.org/10.1039/C0CC00588F
Article type
Communication
Submitted
25 Mar 2010
Accepted
03 Jun 2010
First published
24 Jun 2010

Chem. Commun., 2010,46, 5787-5789

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Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium(salalen) catalyst

Y. Sakai, J. Mitote, K. Matsumoto and T. Katsuki, Chem. Commun., 2010, 46, 5787 DOI: 10.1039/C0CC00588F

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