Issue 19, 2010

Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines

Abstract

A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions.

Graphical abstract: Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines

Supplementary files

Article information

Article type
Communication
Submitted
26 Jan 2010
Accepted
01 Mar 2010
First published
25 Mar 2010

Chem. Commun., 2010,46, 3357-3359

Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines

L. Zhang, X. Xu, J. Tan, L. Pan, W. Xia and Q. Liu, Chem. Commun., 2010, 46, 3357 DOI: 10.1039/C001617A

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