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Issue 42, 2009
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MRI contrast agent delivery using spore capsules: controlled release in blood plasma

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Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd–DTPA–BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Graphical abstract: MRI contrast agent delivery using spore capsules: controlled release in blood plasma

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Supplementary files

Article information


Submitted
13 May 2009
Accepted
08 Sep 2009
First published
01 Oct 2009

Chem. Commun., 2009, 6442-6444
Article type
Communication

MRI contrast agent delivery using spore capsules: controlled release in blood plasma

M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie and S. J. Archibald, Chem. Commun., 2009, 6442
DOI: 10.1039/B909551A

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