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Issue 8, 2009
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Inhibition of selectin binding by colloidal gold with functionalized shells

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Abstract

Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC50 values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

Graphical abstract: Inhibition of selectin binding by colloidal gold with functionalized shells

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Supplementary files

Article information


Submitted
15 Oct 2008
Accepted
15 Dec 2008
First published
15 Jan 2009

Chem. Commun., 2009, 932-934
Article type
Communication

Inhibition of selectin binding by colloidal gold with functionalized shells

J. Dernedde, S. Enders, H. Reissig, M. Roskamp, S. Schlecht and S. Yekta, Chem. Commun., 2009, 932
DOI: 10.1039/B818263A

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