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Issue 8, 2009
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Inhibition of selectin binding by colloidal gold with functionalized shells

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Abstract

Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC50 values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

Graphical abstract: Inhibition of selectin binding by colloidal gold with functionalized shells

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Publication details

The article was received on 15 Oct 2008, accepted on 15 Dec 2008 and first published on 15 Jan 2009


Article type: Communication
DOI: 10.1039/B818263A
Citation: Chem. Commun., 2009,0, 932-934

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    Inhibition of selectin binding by colloidal gold with functionalized shells

    J. Dernedde, S. Enders, H. Reissig, M. Roskamp, S. Schlecht and S. Yekta, Chem. Commun., 2009, 0, 932
    DOI: 10.1039/B818263A

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