Issue 8, 2009
From the journal:

Chemical Communications

Inhibition of selectin binding by colloidal gold with functionalized shells†

Jens Dernedde,a   Sven Enders,a   Hans-Ulrich Reissig,b   Meike Roskamp,b   Sabine Schlecht*b  and  Shahla Yektab  

* Corresponding authors

a Charité-Universitätsmedizin Berlin, CBF, Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Hindenburgdamm 30, 12203 Berlin, Germany
E-mail: jens.dernedde@charite.de

b Freie Universität Berlin, Institut für Chemie und Biochemie, Fabeckstrasse 34-36, 14195 Berlin, Germany
E-mail: schlecht@chemie.fu-berlin.de
Fax: +49 (0)30 83853310

Abstract

Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC50 values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

Graphical abstract: Inhibition of selectin binding by colloidal gold with functionalized shells

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Article information

DOI
https://doi.org/10.1039/B818263A
Article type
Communication
Submitted
15 Oct 2008
Accepted
15 Dec 2008
First published
15 Jan 2009

Chem. Commun., 2009, 932-934

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Inhibition of selectin binding by colloidal gold with functionalized shells

J. Dernedde, S. Enders, H. Reissig, M. Roskamp, S. Schlecht and S. Yekta, Chem. Commun., 2009, 932 DOI: 10.1039/B818263A

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