Issue 8, 2009
From the journal:

Chemical Communications

Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator†

Qinpeng Shen,a   Zhou Nie,*a   Manli Guo,a   Chuan-Jian Zhong,b   Bin Lin,c   Wang Lia  and  Shouzhuo Yaoa  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, PR China
E-mail: niezhou.hnu@gmail.com
Fax: +86-731-8821848
Tel: +86-731-8821968

b Department of Chemistry, State University of New York at Binghamton, Binghamton, New York, USA

c Structural and Computational Biology & Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, USA

Abstract

The sequence-length-dependent adsorption of single-stranded DNA (ssDNA) on unmodified gold nanoparticles is exploited as a new mechanism for colorimetric nuclease assay and measurement of oxidative DNA damage.

Graphical abstract: Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator

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Article information

DOI
https://doi.org/10.1039/B818081D
Article type
Communication
Submitted
14 Oct 2008
Accepted
02 Dec 2008
First published
14 Jan 2009

Chem. Commun., 2009, 929-931

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Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator

Q. Shen, Z. Nie, M. Guo, C. Zhong, B. Lin, W. Li and S. Yao, Chem. Commun., 2009, 929 DOI: 10.1039/B818081D

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