Issue 44, 2009
From the journal:

Chemical Communications

SERS detection and boron delivery to cancer cells using carborane labelled nanoparticles†

David C. Kennedy,a   Dominique R. Duguay,b   Li-Lin Tay,c   Darrin S. Richesonb  and  John P. Pezacki*ab  

* Corresponding authors

a Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Canada
E-mail: John.Pezacki@nrc-cnrc.gc.ca

b Chemistry Department, University of Ottawa, 10 Marie Curie, Ottawa, Canada

c Institute for Microstructural Sciences, National Research Council Canada, 1200 Montreal Road M-50, Ottawa, Canada

Abstract

Water-soluble carborane functionalized nanoparticles also co-functionalized with targeting antibodies have been prepared. We demonstrate tumour cell targeting with anti-EGFR antibodies and delivery of a high concentration of boron using SERS imaging. This suggests these materials have a therapeutic potential in addition to multimodal imaging capabilities.

Graphical abstract: SERS detection and boron delivery to cancer cells using carborane labelled nanoparticles

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Article information

DOI
https://doi.org/10.1039/B916561D
Article type
Communication
Submitted
11 Aug 2009
Accepted
28 Sep 2009
First published
15 Oct 2009

Chem. Commun., 2009, 6750-6752

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SERS detection and boron delivery to cancer cells using carborane labelled nanoparticles

D. C. Kennedy, D. R. Duguay, L. Tay, D. S. Richeson and J. P. Pezacki, Chem. Commun., 2009, 6750 DOI: 10.1039/B916561D

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