Issue 45, 2008

A new physicochemical characterization of sodium taurodeoxycholate/water system

Abstract

In this paper, some new physicochemical properties of sodium taurodeoxycholate (STDC)–water system are carefully investigated using shear rheology and NMR diffusometry. Of clear interest to us was the study of structure and/or morphology of the isotropic liquid and the hexagonal phase.

We observed that the isotropic liquid phase (C < 30 wt% STDC) consists of a micellar solution (L1) and presents a sharp structural transition from spherical micelles to an entangled network upon increasing the concentration. Below 10 °C, the L1 phase transforms slowly into a firm, gel phase (V) which results stable in the composition interval 15 < C < 30 wt%. The linear viscoelasticity of this phase is interpreted by means of the cooperative-flow theory.

The liquid crystalline phase (36 < C < 65 wt% STDC) is unequivocally characterized as having a direct hexagonal structure (H1). Specifically, the hexagonal mixture with 45 wt% STDC presents a low thermal stability (T < 35 °C) and slow kinetics at the liquid–hexagonal transition (>5 hours). The linear viscoelasticity of this phase is interpreted by means of the generalized Maxwell model.

All these findings are confirmed by some additional measurements performed on a lyotropic mixture of hexaethylene glycol monododecyl ether (C12E6), a nonionic surfactant forming a direct hexagonal phase in a similar interval of compositions and temperatures of STDC.

Graphical abstract: A new physicochemical characterization of sodium taurodeoxycholate/water system

Supplementary files

Article information

Article type
Paper
Submitted
09 Jun 2008
Accepted
28 Jul 2008
First published
09 Oct 2008

Phys. Chem. Chem. Phys., 2008,10, 6880-6889

A new physicochemical characterization of sodium taurodeoxycholate/water system

M. Youssry, L. Coppola, E. Furia, C. Oliviero and I. Nicotera, Phys. Chem. Chem. Phys., 2008, 10, 6880 DOI: 10.1039/B809582E

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