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Issue 29, 2008
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A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

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Abstract

Total syntheses of the potent neurotoxins, environmental hazards, and biochemical probes anatoxin-a and homoanatoxin have been achieved from a common intermediate using a combined two-directional synthesis–tandem reaction strategy which includes key advances in oxidative desymmetrisation, tandem Michael–intramolecular Mannich cyclisations and a new method for deprotection of N-tosyl anatoxin-a.

Graphical abstract: A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

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Publication details

The article was received on 12 Mar 2008, accepted on 22 Apr 2008 and first published on 23 May 2008


Article type: Communication
DOI: 10.1039/B804304C
Citation: Chem. Commun., 2008,0, 3432-3434

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    A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

    S. J. Roe and R. A. Stockman, Chem. Commun., 2008, 0, 3432
    DOI: 10.1039/B804304C

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