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Issue 36, 2008
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Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

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Abstract

The helicity of the (SSS)-Δ enantiomer of a terbium and europium(III) complex is inverted on reversible binding to ‘drug site II’ of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

Graphical abstract: Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

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Publication details

The article was received on 27 Jun 2008, accepted on 15 Jul 2008 and first published on 10 Sep 2008


Article type: Communication
DOI: 10.1039/B810978H
Citation: Chem. Commun., 2008,0, 4261-4263

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    Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

    C. P. Montgomery, E. J. New, D. Parker and R. D. Peacock, Chem. Commun., 2008, 0, 4261
    DOI: 10.1039/B810978H

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