Issue 3, 2008
From the journal:

Analyst

Target-induced strand release (TISR) from aptamer–DNA duplex: A general strategy for electronic detection of biomolecules ranging from a small molecule to a large protein†

Jyun Yoshizumi,a   Satoshi Kumamoto,a   Mitsunobu Nakamuraa  and  Kazushige Yamana*a  

* Corresponding authors

a Department of Materials Science and Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Japan
E-mail: yamana@eng.u-hyogo.ac.jp
Fax: +81 79-267-4895
Tel: +81 79-267-4895

Abstract

We describe a general strategy for electronic aptamer-based biosensor that is based on target-induced strand release (TISR) of a redox-modified aptamer from the aptamer-capture DNA duplex bound on an electrode.

Graphical abstract: Target-induced strand release (TISR) from aptamer–DNA duplex: A general strategy for electronic detection of biomolecules ranging from a small molecule to a large protein

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Article information

DOI
https://doi.org/10.1039/B719089C
Article type
Communication
Submitted
10 Dec 2007
Accepted
17 Dec 2007
First published
10 Jan 2008

Analyst, 2008,133, 323-325

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Target-induced strand release (TISR) from aptamer–DNA duplex: A general strategy for electronic detection of biomolecules ranging from a small molecule to a large protein

J. Yoshizumi, S. Kumamoto, M. Nakamura and K. Yamana, Analyst, 2008, 133, 323 DOI: 10.1039/B719089C

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