Issue 3, 2008
From the journal:

Analyst

Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection

Yi-Chin Toh,†ab   Jing Zhang,†a   Yuet Mei Khong,abc   Yanan Du,ab   Wanxin Suna  and  Hanry Yu*abcdef  

* Corresponding authors

a Institute of Biotechnology and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, Singapore 138669, Singapore
E-mail: hyu@ibn.a-star.edu.sg
Tel: 0065-6516 3466

b NUS Graduate School for Integrative Sciences and Engineering, Graduate Program in Bioengineering, Centre for Life Sciences (CeLS), #05-01, 28 Medical Drive, Singapore 117456, Singapore

c Department of Physiology, Yong Loo Lin School of Medicine, #03-03, 2 Medical Drive, Singapore 117597, Singapore

d Singapore-MIT Alliance, E4-04-10, 4 Engineering Drive 3, Singapore 117576, Singapore

e NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore 117597, Singapore

f Department of Haematology-Oncology, National University Hospital, Singapore 119074, Singapore

Abstract

We report the establishment of capillary electrophoresis with laser-induced fluorescence (CE–LIF) detection as a common analytical platform for sensitive quantification of both phase I and II metabolism in various hepatic in vitro models.

Graphical abstract: Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection

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Article information

DOI
https://doi.org/10.1039/B716420C
Article type
Communication
Submitted
25 Oct 2007
Accepted
24 Jan 2008
First published
05 Feb 2008

Analyst, 2008,133, 326-330

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Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection

Y. Toh, J. Zhang, Y. M. Khong, Y. Du, W. Sun and H. Yu, Analyst, 2008, 133, 326 DOI: 10.1039/B716420C

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