Nucleophilic activity of a linked bis{guanidine} leading to formation of a dicationic C4N4-heterocycle

Martyn P. Coles; Steven F. Lee; Sarah H. Oakley; Guillermina Estiu; Peter B. Hitchcock

doi:10.1039/B715209D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Nucleophilic activity of a linked bis{guanidine} leading to formation of a dicationic C₄N₄-heterocycle†

Martyn P. Coles,*^a Steven F. Lee,^a Sarah H. Oakley,^a Guillermina Estiu^b and Peter B. Hitchcock^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Sussex, Brighton, Falmer, UK
E-mail: m.p.coles@sussex.ac.uk
Fax: +44 (0)1273 677196
Tel: +44 (0)1273 877339

^b Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556-5670, USA

Abstract

The methylene-linked bis{guanidine}, H₂C{hpp}₂ (hppH = 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine), displays nucleophilic activity towards organic halides, including the activation of dichloromethane under ambient conditions affording the cyclic dication, [H₂C{hpp}₂CH₂]²⁺[Cl]₂.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/B715209D
Article type: Communication
Submitted: 03 Oct 2007
Accepted: 23 Oct 2007
First published: 02 Nov 2007

Download Citation

Org. Biomol. Chem., 2007,5, 3909-3911

Permissions

Request permissions

Nucleophilic activity of a linked bis{guanidine} leading to formation of a dicationic C₄N₄-heterocycle

M. P. Coles, S. F. Lee, S. H. Oakley, G. Estiu and P. B. Hitchcock, Org. Biomol. Chem., 2007, 5, 3909 DOI: 10.1039/B715209D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry